Combination chemotherapy with L-asparaginase (EC-2) using P1798 lymphosarcoma
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منابع مشابه
Inhibition of thymidine and basic amino acid metabolism in P1798 lymphosarcoma by L-asparaginase.
In vivo metabolism of lysine and arginine is markedly inhibited (p < 0.025) in P1798 lymphosarcoma within 1 hr after intraperitoneal injection of 1 unit of Escherichia coli L-asparaginase II. Two hr after treatment, there is substan tial inhibition of thymidine transport but no effect on incorporation of thymidine. None of these effects were observed in the L-asparaginase-resistant subline of t...
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L-Asparaginase was used to treat 40 patients with acute leukaemia or lymphosarcoma. Fifteen with acute lymphoblastic leukaemia either untreated or in relapse after previous therapy were given "Squibb," "Bayer," or "Porton" L-asparaginase. Five of these patients had complete remission of their disease, and four had good partial remission. Eleven patients with acute myeloid leukaemia were treated...
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Survival times of C57BL/6J X DBA/2J Fj mice, inoculated with LI210 or LSI78Y ascites tumor cells, were monitored following treatment with cytosine arabinoside, L-asparaginase, and 6-azauridine, alone and in combination. Each tumor line was sensitive to cytosine arabinoside. L-Asparaginase produced cures (60-day survivors) in 20 to 30% of L5178Y hosts but was totally ineffective against L1210. 6...
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RNase activity increases in P1798 lymphoid tumors main tained in BALB/c mi ce that are undergoing irevitro drug-induced regression. Corticosteroids, 5-fluorouracil, vincristine, vinblastine, methotrexate, and triethylenemelamine produce re gression of appropriate sublines of P1798 lymphosarcoma as well as an increase in RNase activity. Numerous other agents tested had no effect either on tumor ...
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T HE CHEMOTHERAPEUTIC MANAGEMENT of patients with lymphosarcoma and reticulum cell sarcoma has usually been accomplished with single agents. The alkylating agents cyclophosphamide and chlorambucil have been widely used,’3 while of the ymca alkaloids, vincristine appears most effective.46 The efficacy of corticosteroids in varying dosages was shown several times.7’8 The remission induction rates...
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ژورنال
عنوان ژورنال: Cancer
سال: 1971
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(1971)28:5<1321::aid-cncr2820280535>3.0.co;2-i